Nanotechnology Nanofiber Scaffolds


The MediVet Nanotechnology lines of scaffolds consist of 3D electro spun nanofiber scaffolds for regenerative medicine and tissue engineering. These scaffolds are made from 100% FDA-approved synthetic materials.

Furthermore, they do not require any animal-derived products to function properly, allowing scaffolds to be used for multiple clinical applications. Nanofibers range in diameter from a micron to a nanometer allowing scaffolds to replicate the extracellular matrix. Found naturally in the body, this provides tissue level support in all multi-cellular organisms. This technology guides cellular growth, causing cells to replicate and differentiate in vivo to form fully functional tissue. Biodegradability is an engineering advancement that can be tailored to coincide with natural metabolic processes, resulting in resorption and replacement with natural tissue.

Available Options for Veterinarians:

  • Wounds (NanoCare-V)
  • Surgical Mesh (NanoMesh)
  • Specially Designed Implants (Nano-I)

NanoCare-V Innovation in Wound Healing


The NanoCare-V line provides Veterinarians a new alternative to healing non-closing wounds. The product can be purchased in sizes that meet your patients’ needs and even re-sterilized to be utilized at a later date. All NanoCare-V patches carry a two year shelf life. The patch can be applied directly to wound bed or surgically sutured for more complex angled cases.

NanoCare-V Case Studies


The dog pictured below was to undergo a skin graft or amputation due to the severity of the injury. The infected wound spanned three quarters length around the leg and is shown below. After debriding the wound bed the NanoCare-V patch was adhered to the site of injury. Over the course of 8 weeks this wound was closed.

 

Pressure Wound Day Zero

Day 0

Pressure Wound Week 4 to Week 8

Week 4 & Week 8

Equine Hay Rake Accident


Horse injured in hay rake accident
Equine Wound Covered w NanoCare V Mesh

This injury was the result of a hay rake accident.  The case was presented with a surface area too great to attempt any type of clinical management.  Looking closely at time 0, the picture displays the NanoCareV patches as a patch work applied directly to the wound bed.  As the pictures indicate, over a period of 4 months, the NanoCareV patches provided epitheliazation and closure of the wound.

 

Equine 3 Months Epithelialization and hair Regrowth
Equine 4 Weeks Granulation Tissue Regrown
Equine Epithelialization and hair Regrowth 2 Months after Medivet NanoCare V was applied
Equine 4 Months Epithelialization and hair Regrowth

Chronic Pressure Necrosis Wound


LEFT: Immediately after engraftment of Medi-Patch NanoWound Care

RIGHT: 4 weeks later

NOTE: Additional patch applied at the end of week 2

NanoMesh – Safety & Strength in Surgical Application


NanoMesh is a synthetic, nanofiber graft made of FDA approved polymers and designed for use as a temporary surgical mesh for use in hernia repair and other soft tissue reconstructive surgeries. Nanofiber meshes have sufficient strength for use in reconstructive applications, yet they are also soft and flexible, which limits patient discomfort [1]. Nanofibers also promote cell adhesion and proliferation, as well as collagen deposition and remodeling [2]. This strengthens the wound interface and reduces the probability of recurrence. The in vivo resorption period is approximately 9 months.

500µm Thick, Available in 1”x1”, 2”x2”, 2”x4”, and 4”x8” Sizes

 

 

MediVet Nano-I: The Future of Tissue Engineering through Nanofiber & Regenerative Medicine


MediVet Nano-I or NanoImplants can be tailor made to meet specific diseases or injuries. This controlled preservation of scaffold implantation is mediated by custom-tailored degradation of the implant based on layer and functional necessity. Consisting of 100% FDA-approved polymers, scaffolding is accepted as native tissue without need for immune system or white cell response.

tracheal regeneration graft

 

Pictured Above: Tracheal Regeneration Graft

 

Equine Tendon Regeneration Graft screen shots from Equine Tendon Replacement video

Pictured Above: Equine Tendon Regeneration Graft (see below video)

 

Equine Transplant Video


 

These custom 3-dimensional biodegradable products are available in a variety of sizes for large and small animals. This revolutionary medical advance is capable for providing suitable scaffolding for a variety of applications—both traumatic and atraumatic:

  • Flexor Tendons
  • Cruciate Ligaments
  • Suspensory Ligaments
  • Extensor Tendons and Ligaments
  • Veins/Arteries
  • Endothelial tissue
  • Organs
  • Cartilage
  • Ocular Discs

 

 

References


 

  1. Ebersole, G.C., et al., Development of novel electrospun absorbable polycaprolactone (PCL) scaffolds for hernia repair applications. Surgical Endoscopy and Other Interventional Techniques, 2012. 26(10): p. 2717-2728.
  2. Plencner, M., et al., Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-epsilon-caprolactone nanofibers and growth factors for prevention of incisional hernia formation. International Journal of Nanomedicine, 2014. 9: p. 3263-3277.

 

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